This updated edition has sections on biology, immunology, etiology, genetics, screening and prevention, and revised chapters on principles of cancer pathology, imaging, interventional radiology, endoscopy, surgical oncology, radiation oncology and medical oncology. All therapies, including chemotherepeutic agents and endocrine therapy, are given. The text includes extensive material on biotherapeutics including immunostimulants, monoclonal serotherapy and gene therapy There is new information on cancer by body system, including the eye, CNS, GU tract, breast, skin, bone and soft tissue; and enhanced coverage of paediatric cancer, management of pain, complications and infections and patient care. A CD-ROM of the complete text, with additional material not included in the print version, and access to the Holland and Frei web site, where readers can obtain updates and new material, are included.