This is a comprehensive, up-to-date statement of the author’s original ideas and practical methods on motivation. In Section I, Reiss discusses the scientific discovery of 16 basic desires or human needs common to everyone and deeply rooted in human nature. In Section II, he shows how 16 basic desires determine personality traits, express core values, and play out in relationships at work, home, and in athletic pursuits. Section III is an updated summary of implications for self-discovery, business, education, sports, and spirituality.